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The lung:tissue ratio for the ∼160 nm αPV1 LNP (Figure 4C) varied between 2 and 3. Previous studies have shown that nanoparticle elasticity is critical for targeting αPV1 when the nanoparticle size exceeds 100 nm.20 LNPs are fluidic in nature and typically exhibit a Young’s moduli of 100 nm.
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